Is important researching the relation between obesogenicity with the space of the cities? How reasons do you give to assess this issue?

Several authors, such as Downs et al. (2020), Mendes et al. (2022); Recine et al.(2022), and Story et al. (2008) address obesity as part of the pandemic frameworks that make up the global obesity/malnutrition syndemic, aggravated by climate change caused by anthropogenic causes. This framework is structured to characterize, then, biological, social and economic interactions of the population, directing to different comorbidities frameworks. Those authors, however, point out that the concept of syndemic does not refer only to comorbidity, but encompasses the result of interactions between multiple and complex variables that result in an unfavorable urban health situation and a higher Health Vulnerability Index (which is constituted of 16 indicators, considering the dimension of urban infrastructure, human capital and income and work (IPEA, 2022)).
As a result, it is observed, for example, that most studies in the area of ​​Architecture and Urbanism and Urban Health tend to investigate urban characteristics, urban metrics and perceptive studies, and their relationships with people's behavior in prioritizing the use of more active modes of transport. However, the focus of this article expands the approach to the investigation of dynamics that can be associated with the urban food system, and that can be understood as a set of elements and activities associated with the production, processing, distribution, preparation and consumption of food, considering , among other aspects, the environment, processes, institutions, people, input and infrastructure (DOWNS et al., 2020; GLANZ et al., 2005; RECINE, BRITO, 2022).

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Babak Khoshnood
Obesity, as essentially all chronic health conditions and illnesses is multi-factorial with complex interactions between obvious factors such as food consumption (amount / type of food / nutritional content / processed...) and exercise / activity. The balance is either caloric excess which leads to obesity or caloric deficit which results in weight - including fat loss and balanced calories which results in maintaining the current weight.
An important part of physicial activity is walking / other outdoor activities and clearly the physical and other characteristics of the environment - work and home - can affect the amount of physical activity and hence the level of energy expenditure which can in turn result in obesity if the physical environment is "hostile" / not friendly to outside activities due to say poor urban planning, lack of parks / green spaces / absence of walking paths / security issues.
So in short yes I think it is important to study the geographic and urban aspects of work and living conditions in order to have a fuller understanding of factors that can contribute to obesity or inversely help obese patients lose weight by favoring physical activities. There is also of course access to fresh high quality food which is often a problem for population groups that are less afluent of live in certain neighborhoods.
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Rafia Azmat
Obesity is related to hormonal disorders, too, linked with junk, processed food,  fried chips,  meat, and burgers and the use of plastic containers given by food shops in big cities. 
The research in big cities should be taken into consideration and developed awareness among the people.  

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Rolf Teschke
Fighting against obesity needs more stringent approaches at sites of fast food production and consumptioni including informatiom in schools. 
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Azevedo,Luís Peres
The consumption of industrialized food  with packs ready to quickly eating , generates a low discharge of energy . The process of manipulation of  food, processing then like vegetables, meat and bread , generates a  higher  comsumption of energy. Other factors, like aditives for conservation and contamination with plastics can possibly contribute to obesity in the modern cities.