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Why do in vitro studies often show ideal results for new techniques, while clinical outcome studies show no significant difference compared to conventional treatments?
In Endodontics specifically: 1. Irrigation techniques (e.g., GentleWave, PUI): • In vitro: Often show superior bacterial reduction compared to conventional syringe irrigation. • Outcome studies: Many show no statistically significant difference in long-term healing or success rates (e.g., JOE 2022, 2024 papers). • 2. Root canal sealers (e.g., bioceramics vs epoxy): • In vitro: Bioceramic sealers demonstrate better properties (e.g., antimicrobial, biocompatibility). • Outcome studies: No...
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