Pings
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12 Answers 3 Votes
Any herbal medicines used for hepatitis, possible mechanism of action, and if possible attached pictures of plants with citations
Any herbal medicines used for hepatitis, possible mechanism of action, and if possible attached pictures of plants with citations
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10 Answers 8 Votes
Why Covid cases are still increasing and not under the control?
Why Covid cases are still increasing and not under the control?
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7 Answers 0 Votes
How long does it take for a glycoprotein to be synthesised de novo, processed in the ER/Golgi apparatus and transported to the cell membrane?
The trafficking time probably depends on the specific protein, but a ballpark average time is what I'm after. Please include references or examples.
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Answer Accepted 1 Answer 1 Vote
Can Levodopa and Renin-angiotensin system alter the intercellular tight junction (TJ) proteins in the epithelial cells in colorectal adenocarcinoma cell line (in vitro)?
Colorectal adenocarcinoma cell line (Caco-2) express tight junctions from 17-21 days. Levodopa is the precursor of dopamine, a well-known neurotransmitter, owever it also porduce effect in the gut. The renin-angiotensin system is responsible for maintaining homeostais and regulate blood pressure and volume.
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1 Answer 0 Votes
What is the most potential drug candidate in computer-aided drug design?
The drug-discovery process is highly costly and time-consuming. Thus, computer-aided drug design has become a very popular field and got applications. As the drug is used in human subjects, the protocol/technique/procedure to drug-design should be highly generalized and comprehensive. Generally high docking-scored drugs are considered best drug-candidates. I guess we should also check whether the best-scored drug satisfies any of the ADMET parameters. I think the optimum scored drug is...
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4 Answers 3 Votes
How do you call an outcome if you have multiple endpoints to investigate it?
Hello, When you want to investigate exacerbations (outcome of interest) in asthma, you can measure: 1) the incidence rate in the last year (i.e. mean numbers of exacerbations in the last year in your total population); 2) the frequency of patients reporting one exacerbation in the last year; 3) the time-to-1st-exacerbation within the last year. So you have 3 different endpoints to explore the same outcome. Could you please help me in finding the technical term to define this property of the...
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1 Answer 0 Votes
Is the role of ceramides in neurodegenerative diseases?
Ceramides, a class of lipid molecules, have been implicated in the pathogenesis of neurodegenerative diseases. Elevated levels of ceramides have been associated with cellular stress, inflammation, and apoptosis, which are processes involved in neurodegeneration. Researchers are investigating the specific mechanisms through which ceramides contribute to diseases like Alzheimer's and Parkinson's, aiming to understand their role and potential therapeutic interventions targeting ceramide pathways.
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5 Answers 1 Vote
How do carbon nanotubes prove beneficial in medical health care?
Nanotechnology in Medicine
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Answer Accepted 7 Answers 2 Votes
Data fabrication, p-hacking and biased peer review are issues with published papers. In your opinion, how can we fix this problem as a scientific community?
Recently, these issues have been brought up in many fields, resulting in retraction of important papers and investigation on the data produced by prominent scientists. That undermines the trust I used to put in published data, granted that we are always skeptical in science, but we always move forward basing our new hypothesis on what has been published. I wonder how can we help to improve the trustworthiness of published data.
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Answer Accepted 8 Answers 0 Votes
What is the relationship between free radicals and the inflammation process during Chronic diseases?
OxInflammation process is a complex and systemic event that occurs after cellular and tissue injury. The knowledge about both processes is that they coexist, but already known that possibly the inflammatory response is responsible for the generation of a pro-oxidative environment due to the production of Free radicals and Reactive Oxygen species (ROS), especially in chronic diseases. In normal tissue occurs the activation of efficient machinery able to control the oxidative stress, however,...
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